Logistics providers are challenged to rapidly establish medical supply chains to deliver serums of unparalleled amounts of more than 10 billion doses worldwide with first emergency use authorisations for COVID-19 vaccines expected to be effective in the last quarter of 2020. Currently, more than 250 vaccines across seven platforms are being developed and trialled. As COVID-19 vaccines have leapfrogged development phases, stringent temperature requirements (up to -80°C) are likely to be imposed for certain vaccines to ensure that their efficacy is maintained during transportation and warehousing. This poses novel logistics challenges to the existing medical supply chain that conventionally distributes vaccines at ~2–8°C. In the paper, DHL evaluates how the transport of vaccines as highly temperature-sensitive product can be managed effectively to combat the further spread of the virus